We describe the validation of DBS samples against matched serum in a highly sensitive and specific SARS-CoV-2 ELISA. Nevertheless, the potential role of DBS sampling in studying SARS-CoV-2 seroprevalence has not been fully explored, and knowledge regarding the recovery of antibody from the DBS is limited. Moreover, DBS sampling provides a solution to widening access to serologic platforms in low- and middle-income countries. It is a well-established method for detecting antibodies against various infections ( 5, 6), and antibodies collected by DBS are stable for prolonged periods ( 7). In contrast, dried blood spot (DBS) sampling is simple, inexpensive, and can be self-collected and then sent by postal services to laboratories for processing ( 4). The use of such sampling in large-scale seroepidemiologic studies is limited by logistic challenges, resources, and costs, as well as the risk for SARS-CoV-2 exposure from direct patient contact. data, ) and in determining prior virus exposure at a population level ( 1), knowledge which could substantially influence public health and social policies ( 2, 3).Ĭurrently, antibody testing for SARS-CoV-2 uses serum or plasma collected by venipuncture. In contrast, although serologic testing is less useful for diagnosing the acute stages of infection, it can aid in diagnosing atypical manifestations of SARS-CoV-2 infection (M. A confirmed diagnosis of acute coronavirus disease (COVID-19) depends on the detection of RNA from the causative pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
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